Tris(benzotriazol-1-yl)methane: A-CO2H Synthon for the Preparation of Carboxylic Acids
- 1 January 1990
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1990 (08) , 666-669
- https://doi.org/10.1055/s-1990-26975
Abstract
Lithiation of tris(benzotriazol-1-yl)methane 16 gives the tris(benzotriazolyl)methyl carbanion 17 which affords substitution products 18 with many electrophiles. Acidic hydrolysis of 18 affords the corresponding carboxylic acids 19 in good yield. The syntheses of several α-functionalized carboxylic acids are described.Keywords
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