In Vivo Adaptation of the Wayne Model of Latent Tuberculosis
- 1 May 2007
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 75 (5) , 2621-2625
- https://doi.org/10.1128/iai.00918-06
Abstract
Cultures of Mycobacterium tuberculosis grown under oxygen depletion conditions enter into a state of nonreplicating persistence that may reflect a physiologically latent state. When these cultures were harvested and injected intranasally into mice, no bacteria could be recovered from the lungs for about 3 weeks, but after that evidence of regrowth was observed. Preimmunization of mice with a panel of selected vaccine candidates slowed or prevented this event. This simple model has potential for identifying vaccines targeting latent tuberculosis.Keywords
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