Synergistic effect of perfluorochemicals on BCNU chemotherapy

Publisher Website
Google Scholar
Abstract
✓ In a study of the effect of adding perfluorochemicals to BCNU chemotherapy, 7 × 105 9L tumor cells were implanted in the right cerebral hemisphere of Fischer 344 rats weighing about 100 gm each. On the 7th day after implantation, rats were given BCNU or Fluosol-43 (perfluorochemical artificial blood substitute), or a combination of the two, and the therapeutic effects of these treatments were studied. Mean survival time of control animals was 15.23 days ± 2.84 days (standard deviation); in the group treated with Fluosol-43 and kept in an oxygen chamber (95% O2, 5% CO2), survivial time was 15.30 ± 2.11 days. The BCNU treatment alone and BCNU in rats kept in an oxygen chamber prolonged the mean survival time to 20.90 ± 3.80 days and 21.10 ± 2.14 days, respectively. Survival times in rats receiving BCNU plus Fluosol and breathing normal air, BCNU plus dextran-40 and breathing normal air, and BCNU plus dextran-40 in an oxygen chamber were 21.20 ± 2.63 days, 22.90 ± 1.52 days, and 22.20 ± 1.79 days, respecti...