T594M mutation of the epithelial sodium channel β‐subunit gene in pre‐eclampsia and eclampsia in Black South African women
- 23 August 2004
- journal article
- Published by Wiley in BJOG: An International Journal of Obstetrics and Gynaecology
- Vol. 111 (9) , 1012-1013
- https://doi.org/10.1111/j.1471-0528.2004.00221.x
Abstract
The possible role of the β-subunit of the epithelial sodium channel T594M polymorphism in hypertensive disorders of pregnancy has not been examined. This study compared Black South African women with pre-eclampsia (n= 204), early onset pre-eclampsia (n= 67), eclampsia (n= 120) and gestational hypertension (n= 78) with 338 women from the same ethnic group who had full-term normotensive pregnancies, for the presence of the T594M polymorphism. The variant allele was detected in 1.7% to 3.8% of the various patient groups and in 3.6% of the control group reflecting no significant difference. These results suggest that the T594M polymorphism in the sodium channel β-subunit is not associated with the pathogenesis of pre-eclampsia or gestational hypertension.Keywords
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