EXPERIMENTAL PATHOGENESIS OF NON-LETHAL HERPESVIRUS INFECTION AND ESTABLISHMENT OF LATENCY

  • 1 January 1978
    • journal article
    • research article
    • Vol. 22  (4) , 278-+
Abstract
In rabbits inoculated into the right scarified cornea with the Kupka strain of human Herpesvirus type 1 (HHV 1), healing of the keratitis occurred between days 8-12 post infection (p.i.). Viral particles were seen in nuclei and cytoplasm of corneal epithelium cells and in a few fibrocytes of corneal stroma. By immunofluorescence and EM, the virus was demonstrated in sigle neurons and satellite cells of the homolateral Gasserian ganglion since 24 h p.i. From 20 h to 8 days p.i., HHV 1 was found in ganglia of 7 out of 15 rabbits, while the explantation was positive in 10 out of 12 animals. In the course of latency, single HHV antigen-containing cells were seen in ganglia of 3 out of 7 rabbits and virus isolation attempts before explanation always were negative. Viral antigen was found in single ganglion cells only in 2 of rabbits with healed corneal lesions while the explanation of the ganglion tissue yielded HHV at an unchanged high frequency (92% of animals).

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