Anticoccidials. VII. Synthesis of 4,5-dihydro-5-oxo-2-pyrazinecarboxylic acid 1-oxides.
- 1 January 1980
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 28 (10) , 3057-3063
- https://doi.org/10.1248/cpb.28.3057
Abstract
Hydrolysis of 1,6-dihydro-6-oxo-2,3-pyrazinedicarbonitrile (4) gave sodium hydrogen 1,6-dihydro-6-oxo-2,3pyrazinedicarboxylate (6), which was converted to methyl 1,6dihydro-6-oxo-2-pyrazinecarboxylate (10) and methyl 4,5-dihydro-5-oxo-2-pyrazinecarboxylate (12) via a sequence of reactions including decarboxylation and esterification. Although the synthesis of 4,5-dihydro-5-oxo-2-pyrazinecarboxylic acid 1-oxide (2) from 12 was unsuccessful, its 6-methyl derivative 3 was synthesized from the 5-methyl analog of 4.This publication has 2 references indexed in Scilit:
- Anticoccidials. V. Synthesis and anticoccidial activity of 2(1H)-pyrazinone 4-oxide derivatives.CHEMICAL & PHARMACEUTICAL BULLETIN, 1980
- Anticoccidials. IV. A convenient synthesis of 2(1H)-pyrazinone 4-oxide derivatives.CHEMICAL & PHARMACEUTICAL BULLETIN, 1980