Hemoglobin Variations in D-Trisomy Syndrome

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Abstract
IN addition to the now well recognized phenotypic signs, unusual characteristics of hemoglobin composition have been described in infants with D trisomy. Various investigators have noted an increased proportion of fetal hemoglobin in these infants.1 2 3 4 Huehns et al.1 reported that hemoglobin Gower 2 (the presumed embryonic hemoglobin) and hemoglobin Bart's are detectable at birth in such infants. Lee et al.4 likewise found traces of these hemoglobins in an infant with D trisomy. Walzer et al.3 recently described an infant with D trisomy in whom hemoglobin A2 was abnormally low at birth. This finding was further corroborated by Lee et . . .