Failure of dimethyl sulfoxide in the treatment of scleroderma

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Abstract
Nineteen patients with systemic scleroderma and 5 with localized scleroderma were treated with topical dimethyl sulfoxide by painting and immersion techniques. Partial control was obtained by using a very low concentration (5%) on 1 side when involvement was symmetrical. Duration of treatment ranged from 3-15 mo. Topical dimethyl sulfoxide did not improve the skin induration, range of motion or Raynaud''s phenomenon in the scleroderma patients. No substantial beneficial effect was noted on the healing of ischemic ulcers, and the continuous application of dimethyl sulfoxide did not prevent new ulcerations from developing. Relief of pain was noted in 10 of 16 patients, probably due to the local analgesic effect of dimethyl sulfoxide.

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