The Receptor for the Cytotoxic Ligand TRAIL
- 4 April 1997
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 276 (5309) , 111-113
- https://doi.org/10.1126/science.276.5309.111
Abstract
TRAIL (also known as Apo-2L) is a member of the tumor necrosis factor (TNF) ligand family that rapidly induces apoptosis in a variety of transformed cell lines. The human receptor for TRAIL was found to be an undescribed member of the TNF-receptor family (designated death receptor-4, DR4) that contains a cytoplasmic “death domain” capable of engaging the cell suicide apparatus but not the nuclear factor kappa B pathway in the system studied. Unlike Fas, TNFR-1, and DR3, DR4 could not use FADD to transmit the death signal, suggesting the use of distinct proximal signaling machinery. Thus, the DR4-TRAIL axis defines another receptor-ligand pair involved in regulating cell suicide and tissue homeostasis.Keywords
This publication has 22 references indexed in Scilit:
- Apoptosis by Death FactorCell, 1997
- RAIDD is a new 'death' adaptor moleculeNature, 1997
- FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling ComplexCell, 1996
- A License to KillCell, 1996
- Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine FamilyJournal of Biological Chemistry, 1996
- The cell-death machineCurrent Biology, 1996
- Identification and characterization of a new member of the TNF family that induces apoptosisImmunity, 1995
- Contenders in FasL/TNF death signalingCell, 1995
- A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death DomainJournal of Biological Chemistry, 1995
- Mechanisms and Genes of Cellular SuicideScience, 1995