Solubility of inert gases in homogenates of canine lung tissue
- 1 June 1979
- journal article
- research article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 46 (6) , 1207-1210
- https://doi.org/10.1152/jappl.1979.46.6.1207
Abstract
The solubility of sulfur hexafluoride (SF6), ethane, cyclopropane, halothane, diethyl ether, and acetone in homogenates of dog lung tissue were measured and compared with values obtained in dog blood. The measurements were made to provide data for a method for determining distribution of ventilation, blood flow, and tissue volume (Physiologist 20: 95, 1977) and for reasons discussed, the blood was not washed from the tissue prior to homogenization. All gases except SF6 were significantly more soluble in blood than lung tissue, whereas SF6 was 3.7 times more soluble in tissue than blood. It was further found that SF6 is 5 times more soluble, and ethane is twice as soluble in tissue obtained from lungs containing blood than in tissue obtained from rinsed lungs, suggesting that measurements of parenchymal solubility made on tissue from sinsed lungs may be considerably in error for some lipid-soluble gases.This publication has 6 references indexed in Scilit:
- Effect of intrapulmonary hematocrit maldistribution on O2, CO2, and inert gas exchangeJournal of Applied Physiology, 1979
- Solubility of O2 and CO in blood and pulmonary and placental tissue.Journal of Applied Physiology, 1968
- Alterations in the pulmonary capillary bed during early O2 toxicity in man.Journal of Applied Physiology, 1968
- Solubility of inert gases in human lung tissueJournal of Applied Physiology, 1959
- Determination of pulmonary parenchymal tissue volume and pulmonary capillary blood flow in manJournal of Applied Physiology, 1959
- TRANSCAPILLARY MIGRATION OF HEAVY WATER AND THIOCYANATE ION IN THE PULMONARY CIRCULATION OF NORMAL SUBJECTS AND PATIENTS WITH CONGESTIVE HEART FAILURE 123Journal of Clinical Investigation, 1955