Epidermal growth factor binding sites on human erythrocytes in donors with different ABO blood groups

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Abstract
Analysis of epidermal growth factor (125J‐EGF) binding to human red cells revealed the presence of two classes of binding sites with apparent equilibrium dissociation constants (app.Kd) in the 10−10−10−9 M and in the 10−8 M range, respectively. The number of binding sites/cell ranged between 600 and 2,400 for the high‐affinity binding site and between 7,200 and 23,000 for the low‐affinity site. No differences were seen in the apparent Kd values for both types of binding sites between red cells obtained from donors with different ABO‐blood groups. An increase in the number of high affinity EGF binding sites was observed in donors with blood group A,‐erythrocytes as compared to red cells taken from donors with blood groups o and B.