Abstract
Differential inhibition of Gram-negative bacilli of intestinal origin depends on aerobiosis and the nature of the surface on which they are grown as well as on a synergism between bile salts and electrolytes. Electron microscope studies suggest that bile salts increase the cell-wall permeability to electrolytes. The ease with which organisms can be inhibited seems to be directly related to their altered cell-wall permeability. The observations indicate that one factor in the physiol. difference between rough and smooth variants of a single culture is the greater permeability of the rough variant to electrolytes in the presence of bile salts.

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