Immunogenicity of an Escherichia coli (Serotype O1) Pili Vaccine in Chickens

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Abstract
Immunogenicity of an oil-emulsified Escherichia coli (serotype O1) pili vaccine was evaluated in chickens. Chickens were vaccinated with 116 .mu.g or 29 .mu.g of pili protein and challenged with the homologous E. coli via the posterior thoracic air sac. Unvaccinated chickens were challenged to serve as positive controls or left unchallenged to serve as negative controls. Vaccinated chickens were protected against challenge because they (a) suffered low or no mortality; (b) had mild gross lesions in air sacs, pericardial sacs, and livers, and the scored values were significantly (P .ltoreq. 0.05) lower than those in the positive controls; and (c) eliminated E. coli from tissues more efficiently than the positive controls.

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