Investigation of an Outbreak of Hepatitis A in Irish Haemophilia A Patients

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Abstract
Since 1990, Irish haemophilia A patients have been treated with solvent-detergent(SD)-treated virally inactivated high-purity factor VIII concentrate prepared from plasma from Irish voluntary non-remunerated donors. In 1992,13 haemophilia A patients developed clinical hepatitis A and a further 17 patients showed serological evidence of recent infection by hepatitis A. All but 3 of these patients had had recent exposure to SD-treated product. A casecontrol study is underway to determine whether these cases represent transmission through product or environmentally acquired hepatitis A.

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