Chemoenzymatic Dynamic Kinetic Resolution of Primary Amines
- 19 November 2005
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 127 (50) , 17620-17621
- https://doi.org/10.1021/ja056306t
Abstract
An efficient process for dynamic kinetic resolution of amines was developed by combining a ruthenium-catalyzed racemization with a lipase-catalyzed resolution. A variety of unfunctionalized primary amines were transformed into one enantiomer of the amide in high yield and high enantioselectivity.Keywords
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