Multidrug transport in human glioblastoma cells is inhibited by transforming growth factors type β1, β2, and β1.2
- 1 February 1991
- journal article
- research article
- Published by Wiley in Journal of Neuroscience Research
- Vol. 28 (2) , 310-314
- https://doi.org/10.1002/jnr.490280218
Abstract
The transforming growth factors type β1, β2 and β1.2 suppress multidrug transport in human pat-1 glioblastoma cells and even in cells that strongly over-express mdr genes and are resistant to inhibition of multidrug transport by chemosensitizers. Thus, inhibition of multidrug transport by cytokines might be a new approach to increase cellular accumulation of chemotherapeutic agents in multidrug resistant glial tumor cells. Interestingly, a member of the more distantly related decapentaplegic subgroup of transforming growth factors, the bone morphogenetic protein BMP 2, did not inhibit multidrug transport.Keywords
This publication has 17 references indexed in Scilit:
- Transforming growth factors type β1 and β2 suppress rat astrocyte autoantigen presentation and antagonize hyperinduction of class II major histocompatibility complex antigen expression by interferon-γ and tumor necrosis factor-αJournal of Neuroimmunology, 1990
- Transforming growth factors β1 and β2: cytokines with identical immunosuppressive effects and a potential role in the regulation of autoimmune T cell functionJournal of Neuroimmunology, 1989
- Correlation of MDR1 Gene Expression With Chemotherapy in NeuroblastomaJNCI Journal of the National Cancer Institute, 1989
- THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCEAnnual Review of Biochemistry, 1989
- Novel Regulators of Bone Formation: Molecular Clones and ActivitiesScience, 1988
- Developmental Expression of PDGF, TGF-α, and TGF-β Genes in Preimplantation Mouse EmbryosScience, 1988
- Reversal of drug‐resistance in multiple myeloma with verapamilBritish Journal of Haematology, 1988
- Expression and secretion of type beta transforming growth factor by activated human macrophages.Proceedings of the National Academy of Sciences, 1987
- The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptorsCell, 1987
- Polypeptide Transforming Growth Factors Isolated from Bovine Sources and Used for Wound Healing in VivoScience, 1983