Embryonic stem-cell culture as a tool for developmental cell biology
- 1 June 2007
- journal article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 8 (6) , 502-507
- https://doi.org/10.1038/nrm2189
Abstract
The cell biology of the early processes of mammalian embryogenesis, such as germ-layer formation, has been technically challenging to study owing to the size and accessibility of mammalian embryos. Embryonic stem cells, which can generate the three germ layers in vitro, are useful for studying embryogenesis at the cellular level. So, how can the study of embryonic stem cells and their differentiation provide a deeper understanding of the cell biology of early development?Keywords
This publication has 57 references indexed in Scilit:
- How is pluripotency determined and maintained?Development, 2007
- Molecular control of pluripotencyCurrent Opinion in Genetics & Development, 2006
- Multimodal imaging of mouse development: Tools for the postgenomic eraDevelopmental Dynamics, 2006
- The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES CellsCell, 2003
- Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem CellsCell, 2003
- Dynamic in vivo imaging of postimplantation mammalian embryos using whole embryo cultureGenesis, 2002
- Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4Cell, 1998
- Pluripotent Cell Lines Derived from Common Marmoset (Callithrix jacchus) Blastocysts1Biology of Reproduction, 1996
- Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.Proceedings of the National Academy of Sciences, 1981
- Establishment in culture of pluripotential cells from mouse embryosNature, 1981