RESPONSE OF TUMOR AND TISSUES OF TUMOR-BEARING ANIMAL TO ADMINISTRATION OF SYNTHETIC ANTIOXIDANT

  • 1 January 1978
    • journal article
    • research article
    • Vol. 24  (3) , 368-372
Abstract
Alterations of lipid antioxidative activity in liver and tumor as well as change in weight of spleen and tumor were studied in mice with hepatoma 22 after administration of synthetic antioxidant 4-methyl-2,6-ditertbutylphenol (ionol) at doses 30 mg/kg and 100 mg/kg during the 6th day of tumor growth. Lipid antioxidative activity responded to administration of ionol in liver tissue similarly in both the intact and tumor-bearing animals. The antioxidative activity was increased after administration of both doses of the antioxidant; it then decreased to the initial level when the dose 30 mg/kg was used and below this level at the dose 100 mg/kg. Both doses of the drug increased the lipid antioxidative activity in tumor. The dose 30 mg/kg of ionol stimulated the growth of the tumor and increased the weight of spleen in tumor-bearing animals while the dose 100 mg/kg inhibited these parameters. Regulation of oxidation of the lipids in tumor appears impaired or altered to another level compared with the oxidation of lipids in normal tissues or in the tissues of tumor-bearing animals.