The Sulphur Metabolism of Pityrosporum ovale and its Inhibition by Selenium Compounds

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Abstract
A medium was developed for the more rapid culture of Pityrosporum ovale. [S35]Methionine was utilized preferentially as sole sulfur source from which cysteine/cystine were synthesized. Growth was less on cysteine, negligible on cystine and nil on inorganic sulfite and sulfate. Selenium disulfide, amorphous sulfur, stable colloidal (red) selenium and selenourea were extremely toxic, entering the organism by diffusion. Tellurium and selenomethionine entered the organism, the latter by active transport, but were not toxic for up to 1 week of incubation although synthesis of [Se75]selenomethionine was demonstrated. Selenite and metallic (black) selenium were not toxic and did not enter the organism. Possible mechanisms of toxicity are discussed.

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