Cefsulodin Penetration into Rat Brain: Extracellular versus Total Concentration
- 1 January 1986
- journal article
- research article
- Published by S. Karger AG in Chemotherapy
- Vol. 32 (5) , 393-398
- https://doi.org/10.1159/000238441
Abstract
Disposition of cefsulodin (125 mg · kg––1) was studied in rat frontal cortex after intravenous injection of a bolus by two methods. In vivo voltametry and high performance liquid chromatography of cefsulodin in brain extracts gave different concentration values. The ratio of concentrations determined by the two methods was similar to the ratio of the extravascular volume to total volume. Thus, these findings evidenced the distribution of cefsulodin in the extravascular fluid of the rat frontal cortex.This publication has 4 references indexed in Scilit:
- Interstitial Fluid Concentrations of Cefsulodin, Azlocillin and CarbenicillinScandinavian Journal of Infectious Diseases, 1981
- Metabolic Fate of SCE-129, a New Antipseudomonal Cephalosporin, After Parenteral Administration in Rats and DogsAntimicrobial Agents and Chemotherapy, 1978
- SCE-129, Antipseudomonal Cephalosporin: In Vitro and In Vivo Antibacterial ActivitiesAntimicrobial Agents and Chemotherapy, 1978
- Protein Binding of AntimicrobialsClinical Pharmacokinetics, 1977