Pentolinium and Hexamethonium Combined with Rauwolfia in the Treatment of Hypertension

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Abstract
IN the treatment of moderate to severe hypertension the experience of most investigators suggests that a centrally acting agent such as Rauwolfia serpentina combined with a ganglionic-blocking drug offers the most potent antihypertensive combination. Rauwolfia in combination with hexamethonium has been used effectively in the outpatient management of hypertension,1 with satisfactory orthostatic reduction in blood pressure but with significant untoward effects attributable to the use of the hexamethonium. Since its introduction2 , 3 to American clinics pentolinium has been reported to offer more prolonged ganglionic blockade, with less severe untoward effects, than hexamethonium.This report is an evaluation of pentolinium used in . . .