Immunofluorescence Studies in Scabies

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Abstract
Direct and indirect immunofluorescence investigations were performed for 11 patients with scabies. All patients had punch biopsies taken from a lesion containing Sarcoptes scabiei, an inflammatory papule which did not contain a mite and normal skin. In 4 patients Ig[immunoglobulin]E deposits were found in the vessel walls of the upper dermis in biopsies containing mites and biopsies of inflammatory papules with no mites. No IgE deposits were found in biopsies of normal skin from the same patients. Two patients had IgM and/or C3 [complement component 3] deposits along the basal membrane in biopsies containing mites and 1 of them also had C3 in this area in the biopsy from a papule with no mite, as well as in normal skin.

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