Coupling Electrophoresis with Ultrafiltration for Improved Processing of Plasma Proteins

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Abstract
The feasibility of coupling electrophoresis with ultrafiltration (electroultrafiltration) in order to increase the flux and improve the selectivity of the ultrafiltration process was demonstrated experimentally for protein solutions [bovine serum albumin; .gamma.-globulin]. An electric field controlled the build-up of retained proteins at the membrane surface. Electroultrafiltration fluxes were 3-5 times greater than normal ultrafiltration fluxes. Retention and separation factors were also higher. The effects of important process variables were studied.