Renal Epithelial Apical Na/Pi Cotransporters

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Abstract
Several mammalian renal Na-dependent transport systems for inorganic phosphate have recently been identified using oocytes Xenopus laevis as an expression system. Expression of cloned transporters in oocytes resulted in Na/Pi cotransport activity with kinetic properties characteristic for proximal tubular apical Na/Pi cotransport. Sequence comparison suggests that renal Na/Pi cotransport systems cloned so far may belong to two different types/families of Na/Pi cotransporters. Localization of corresponding mRNAs and proteins revealed that both types of Na/Pi cotransporter systems are expressed in the apical membrane of proximal tubular cells. Evidence was obtained that one type of cloned renal Na/Pi cotransporter plays an important role in the physiological and pathophysiological regulation of renal Pi reabsorption.

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