Antibody Response in Hematologic Patients

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Abstract
Killed tularemia vaccine (Foshay) was employed because the incidence of naturally-occurring tularemia in this area is low, and the vaccine is not generally available. Thus it could be assumed that any response would be due to a primary antigenic stimulus. A single injection of 0.5 ml of phenolized tularemia vaccine elicited detectable agglutinating antibodies in 67 of 162 (41.4%) patients with hematologic disorders as compared to 45 of 48 (93.7%) in normal controls. Particularly significant was the lack of response in 23 of 25 chronic lymphatic leukemia and in 37 of 57 lymphoma patients. In the latter group only 5 of 27 females as compared to 15 of 30 males exhibited antibodies.

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