QUANTITATIVE STUDY OF PERIPHERAL-NERVE FIBERS IN MOUSE FOLLOWING ADMINISTRATION OF DRUGS .1. AGE-CHANGES IN UNTREATED CBA MICE FROM 3 TO 21 MONTHS OF AGE

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 127  (SEP) , 101-115
Abstract
Changes which occur as the result of the aging process in normal mice were examined in order to provide a baseline for drug-induced changes. At the site of sampling of the sciatic nerve there was insignificant change in the number of myelinated axons present with increasing age. There is a gradual increase in the maximum cross sectional area of individual fibers from 6 mo. onwards. By contrast, maximum axon areas did not increase after the age of 6 mo. Thus there is a slow but considerable increase in myelin thickness with age. These observations were not at variance with those recorded previously but they were obtained more quickly, with less margin for error and using a greater number of axons than is customary.