Translational Selection on Codon Usage in Xenopus laevis
Open Access
- 1 September 2001
- journal article
- research article
- Published by Oxford University Press (OUP) in Molecular Biology and Evolution
- Vol. 18 (9) , 1703-1707
- https://doi.org/10.1093/oxfordjournals.molbev.a003958
Abstract
A correspondence analysis of codon usage in Xenopus laevis revealed that the first axis is strongly correlated with the base composition at third codon positions. The second axis discriminates between putatively highly expressed genes and the other coding sequences, with expression levels being confirmed by the analysis of Expressed sequence tag frequencies. The comparison of codon usage of the sequences displaying the extreme values on the second axis indicates that several codons are statistically more frequent among the highly expressed (mainly housekeeping) genes. Translational selection appears, therefore, to influence synonymous codon usage in Xenopus.Keywords
This publication has 36 references indexed in Scilit:
- CLEANUP: a fast computer program for removing redundancies from nucleotide sequence databasesBioinformatics, 1996
- THE HUMAN GENOME: Organization and Evolutionary HistoryAnnual Review of Genetics, 1995
- DNA sequence evolution: the sounds of silencePhilosophical Transactions Of The Royal Society B-Biological Sciences, 1995
- Codon usage and genome evolutionCurrent Opinion in Genetics & Development, 1994
- The ‘effective number of codons’ used in a geneGene, 1990
- Codon usage and intragenic positionJournal of Theoretical Biology, 1988
- An evolutionary perspective on synonymous codon usage in unicellular organismsJournal of Molecular Evolution, 1986
- ACNUC – a portable retrieval system for nucleic acid sequence databases: logical and physical designs and usageBioinformatics, 1985
- Correlation between the abundance of yeast transfer RNAs and the occurrence of the respective codons in protein genesJournal of Molecular Biology, 1982
- Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: A proposal for a synonymous codon choice that is optimal for the E. coli translational systemJournal of Molecular Biology, 1981