Transcription factors in myeloid development: balancing differentiation with transformation
Top Cited Papers
- 1 February 2007
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 7 (2) , 105-117
- https://doi.org/10.1038/nri2024
Abstract
In recent years, great progress has been made in elucidating the progenitor-cell hierarchy of the myeloid lineage. Transcription factors have been shown to be key determinants in the orchestration of myeloid identity and differentiation fates. Most transcription factors show cell-lineage-restricted and stage-restricted expression patterns, indicating the requirement for tight regulation of their activities. Moreover, if dysregulated or mutated, these transcription factors cause the differentiation block observed in many myeloid leukaemias. Consequently, therapies designed to restore defective transcription factor functions are an attractive option in the treatment of myeloid and other human cancers.Keywords
This publication has 142 references indexed in Scilit:
- Asymmetrical lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitorsThe Journal of Experimental Medicine, 2006
- C/EBPβ is required for 'emergency' granulopoiesisNature Immunology, 2006
- Absence of the transcription factor CCAAT enhancer binding protein α results in loss of myeloid identity in bcr/abl-induced malignancyProceedings of the National Academy of Sciences, 2006
- Loss of C/EBPα cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineageThe Journal of Experimental Medicine, 2005
- Self-renewal of teratocarcinoma and embryonic stem cellsOncogene, 2004
- Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1Nature Genetics, 2004
- Disruption of differentiation in human cancer: AML shows the wayNature Reviews Cancer, 2003
- Thymopoiesis independent of common lymphoid progenitorsNature Immunology, 2003
- Transcriptional Regulation of the Stem Cell Leukemia Gene (SCL) — Comparative Analysis of Five Vertebrate SCL LociGenome Research, 2002
- Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic LineagesScience, 1994