Development of macromolecular Sn(II) complex for preparation of 99Tcm radiopharmaceuticals

1 February 1991

journal article
editorial
Published by Wolters Kluwer Health in Nuclear Medicine Communications

Vol. 12 (2) , 147-152
https://doi.org/10.1097/00006231-199102000-00008

Abstract

Macromolecular Sn(II) complex (R-Sn) was developed using a chelating resin containing aminophosphonic acid groups as a reducing agent of ⁹⁹Tc^m(VII) in the preparation of ⁹⁹Tc^m radiopharmaceuticals. Since Sn(II) was bonded strongly to the resin by chelation, release of Sn from R-Sn was rarely observed in saline solution. ⁹⁹Tc^m labelling with a yield greater than 90% was performed by mixing R-Sn, ⁹⁹Tc^m pertechnetate solution and a ligand, such as human serum albumin and diethylenetriamine pentaacetic acid, for a short time. The ⁹⁹Tc^m radiopharmaceuticals were almost free from Sn(II) and the reducing activity of R-Sn was quite stable despite long-term storage without any special care.

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