A network of electrically coupled interneurons drives synchronized inhibition in neocortex
Top Cited Papers
- 1 September 2000
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 3 (9) , 904-910
- https://doi.org/10.1038/78809
Abstract
The neocortex has at least two different networks of electrically coupled inhibitory interneurons: fast-spiking (FS) and low-threshold-spiking (LTS) cells. Agonists of metabotropic glutamate or acetylcholine receptors induced synchronized spiking and membrane fluctuations, with irregular or rhythmic patterns, in networks of LTS cells. LTS activity was closely correlated with inhibitory postsynaptic potentials in neighboring FS interneurons and excitatory neurons. Synchronized LTS activity required electrical synapses, but not fast chemical synapses. Tetanic stimulation of local circuitry induced effects similar to those of metabotropic agonists. We conclude that an electrically coupled network of LTS interneurons can mediate synchronized inhibition when activated by modulatory neurotransmitters.Keywords
This publication has 43 references indexed in Scilit:
- The Temporal Correlation Hypothesis of Visual Feature IntegrationNeuron, 1999
- Cellular Mechanisms Contributing to Response Variability of Cortical NeuronsIn VivoJournal of Neuroscience, 1999
- Synchronous Membrane Potential Fluctuations in Neurons of the Cat Visual CortexNeuron, 1999
- Input synchrony and the irregular firing of cortical neuronsNature Neuroscience, 1998
- Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitroNature, 1998
- Neural Discharge and Local Field Potential Oscillations in Primate Motor Cortex During Voluntary MovementsJournal of Neurophysiology, 1998
- Synchronized activities of coupled oscillators in the cerebral cortex and thalamus at different levels of vigilance [published erratum appears in Cereb Cortex 1997 Dec;7(8):779]Cerebral Cortex, 1997
- Primary cortical representation of sounds by the coordination of action-potential timingNature, 1996
- Comparison of discharge variability in vitro and in vivo in cat visual cortex neuronsJournal of Neurophysiology, 1996
- Temporal structure in spatially organized neuronal ensembles: a role for interneuronal networksCurrent Opinion in Neurobiology, 1995