ProFit: two‐dimensional prior‐knowledge fitting of J‐resolved spectra

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Abstract
A two‐dimensional fitting procedure is introduced, capable of extracting the full amount of information from 2D J‐resolved magnetic resonance spectroscopic data. The fitting procedure uses a linear combination of 2D model spectra. For reducing the degrees of freedom and increasing robustness, it is divided into a non‐linear outer loop and an inner linear least‐squares fit for the concentrations. In vitro and in vivo experiments on a whole‐body 3 T MR scanner show the detectability of a wide range of metabolites in the human brain, namely total creatine, N‐acetylaspartate, N‐acetylaspartylglutamate, choline‐containing compounds, glutamate, myo‐inositol, glutathione, scyllo‐inositol, γ‐aminobutyric acid, alanine and ascorbic acid. Copyright © 2006 John Wiley & Sons, Ltd.