Hypomelanosis Associated with a Colonic Abnormality
- 1 February 1987
- journal article
- pediatric dermatopathology
- Published by Wolters Kluwer Health in The American Journal of Dermatopathology
- Vol. 9 (1) , 45-50
- https://doi.org/10.1097/00000372-198702000-00010
Abstract
A neonate born of black parents displayed a congenital, dramatic deficiency of most of his normal pigmentation. This was accompanied by a markedly dilated colon and various other defects. Light- and electron-microscopic examination revealed a deficiency in melanin content in the hypopigmented skin as compared to the normally pigmented areas. No other defects were noted. The possibility exists that a single aberration in neural crest development, a neurocristopathy, might be responsible for our patient's multiple congenital defects. Similar conditions in veterinary medicine and human disease are reviewed and compared to this case.Keywords
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