Dual Skin Testing withMycobacterium aviumSensitin and Purified Protein Derivative to Discriminate Pulmonary Disease Due toM. aviumComplex from Pulmonary Disease Due toMycobacterium tuberculosis
Open Access
- 1 March 1998
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 177 (3) , 730-736
- https://doi.org/10.1086/514225
Abstract
Skin testing with Mycobacterium avium sensitin (MAS) RS 10/2 and purified protein derivative (PPD) was conducted on patients with pulmonary disease due to M. avium complex (MAC) or Mycobacterium tuberculosis (MTB) and no known immunodeficiency. Reactions ⩾5 mm to either MAS or PPD were present in 37 (84%) of 44 MAC patients and 28 (97%) of 29 MTB patients. MAC patients had a mean MAS reaction of 13.8 (±8.3) mm and a mean PPD reaction of 3.5 (±8.6) mm (P < .001). MTB patients had a mean MAS reaction of 17.9 (±9.4) mm and a mean PPD reaction of 22.9 (±11.4) mm (P < .001). MAS-dominant skin tests (MAS reaction ⩾5 mm larger than PPD reaction) were present in 32 (73%) of 44 MAC patients and 1 (3%) of 29 MTB patients. MAS-dominant skin tests had a specificity of 97% for discriminating MAC disease from MTB disease.Keywords
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