The synthesis and properties of bradykinin analogues: 1-deamino-, 9-decarboxy-, and 1-deamino-9-decarboxy-bradykinin
- 1 January 1971
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society C: Organic
- p. 748-753
- https://doi.org/10.1039/j39710000748
Abstract
A new synthesis of bradykinin (1) has been developed and adapted to the synthesis of three new analogues of bradykinin, viz. 1-deamino-, 9-decarboxy-, and 1-deamino-9-decarboxy-bradykinin. The biological activities of these analogues have been determined; they demonstrate that the terminal carboxy-group is very important for kinin-like activity whereas the terminal amino-group is less so.Keywords
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