Hypotaurine transport in mouse brain synaptosomal preparations
- 1 May 1983
- journal article
- research article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 118 (1) , 57-60
- https://doi.org/10.1111/j.1748-1716.1983.tb07240.x
Abstract
The transport of hypotaurine, the precursor of the probable neuromodulator taurine, was investigated using mouse brain synaptosomal preparations. Hypotaurine uptake was concentrative, energy- and Na-dependent and strongly inhibited by GABA, L-DABA (L-2,4-diaminobutyric acid) and .beta.-alanine, suggesting interactions with GABA uptake systems. The uptake consisted of only 1 saturable transport component both in adult and in 6-day-old brain, being more efficient in the latter.Keywords
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