Polar Molecular Surface Properties Predict the Intestinal Absorption of Drugs in Humans
- 1 January 1997
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 14 (5) , 568-571
- https://doi.org/10.1023/a:1012188625088
Abstract
Purpose. A theoretical method has been devised for prediction of drug absorption after oral administration to humans. Methods. Twenty structurally diverse model drugs, ranging from 0.3 to 100%...Keywords
This publication has 9 references indexed in Scilit:
- Prodrugs revisited: The “ad hoc” approach as a complement to ligand designMedicinal Research Reviews, 1996
- Correlation of Drug Absorption with Molecular Surface PropertiesJournal of Pharmaceutical Sciences, 1996
- Computation of Brain−Blood Partitioning of Organic Solutes via Free Energy CalculationsJournal of Medicinal Chemistry, 1996
- QSAR analysis of membrane permeability to organic compoundsJournal of Drug Targeting, 1996
- Lipophilicity in Molecular ModelingPharmaceutical Research, 1996
- Comparative Evaluation of the Predictive Power of Calculation Procedures for Molecular LipophilicityJournal of Pharmaceutical Sciences, 1995
- Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cellsBiochemical and Biophysical Research Communications, 1991
- Pharmacokinetic studies on the selectiveβ 1-receptor antagonist metoprolol in manJournal of Pharmacokinetics and Biopharmaceutics, 1974
- Molecular forces governing non-electrolyte permeation through cell membranesProceedings of the Royal Society of London. B. Biological Sciences, 1969