Multiple opioid ligands and receptors in the control of nociception
Open Access
- 19 February 1985
- journal article
- Published by The Royal Society in Philosophical Transactions of the Royal Society of London. B, Biological Sciences
- Vol. 308 (1136) , 299-310
- https://doi.org/10.1098/rstb.1985.0030
Abstract
This paper summarizes the results of recent data characterizing the role of endogenous opioid peptides and opioid receptors in nociception. In addition, evidence is given that antinociception induced by intracerebroventricular injection of opioids into mouse brain is mediated by receptors resembling those mediating the inhibitory action of these substances on the rat vas deferens (putative ξ-receptors). The endogenous ligands for these receptor are β-endorphin and the peptides deriving from proenkephalin A.Keywords
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