Role of AgNOR in diagnosis of thyroid follicular neoplasms on fine‐needle aspiration smears

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Abstract
This is a retrospective study to examine the role of AgNOR in differentiating thyroid follicular carcinoma and adenoma preoperatively on fine‐needle aspiration (FNA) smears. Nineteen histopathology‐proven cases of follicular adenoma and carcinoma were selected for this study. May‐Grünwald‐Giemsa—stained smears were destined and AgNOR staining technique was employed. Significant differences of AgNOR values were observed among follicular carcinoma versus adenoma (P < .05) and follicular carcinoma versus control cases (P < .01). Thereby the AgNOR technique may have some role in differentiating between benign and malignant follicular neoplasms of thyroid. Diagn Cytopathol 1995;12:148–151. © 1995 Wiley‐ Liss, Inc.