CadC Activates pH-Dependent Expression of the Vibrio vulnificus cadBA Operon at a Distance through Direct Binding to an Upstream Region
Open Access
- 15 November 2005
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 187 (22) , 7870-7875
- https://doi.org/10.1128/jb.187.22.7870-7875.2005
Abstract
The Vibrio vulnificus cadBA genes were transcribed as a transcriptional operon by a single promoter, P cadBA , which was activated by CadC in a pH-dependent manner. A direct interaction between CadC and the P cadBA DNA was demonstrated, and a CadC binding site centered at −233.5 was mapped by deletion analyses of P cadBA and confirmed by a DNase I protection assay.Keywords
This publication has 21 references indexed in Scilit:
- Acid stress responses in enterobacteriaFEMS Microbiology Letters, 2006
- Molecular Pathogenesis of Vibrio vulnificus.2005
- Regulation of Vibrio cholerae Genes Required for Acid Tolerance by a Member of the “ToxR-Like” Family of Transcriptional RegulatorsJournal of Bacteriology, 2000
- Pathogenesis ofVibrio vulnificusFEMS Microbiology Letters, 1999
- When protons attack: Microbial strategies of acid adaptationCurrent Opinion in Microbiology, 1999
- Kinetics of expression of the Escherichia coli cad operon as a function of pH and lysineJournal of Bacteriology, 1996
- A glutamate-dependent acid resistance gene in Escherichia coliJournal of Bacteriology, 1996
- A consensus sequence for binding of Lrp to DNAJournal of Bacteriology, 1995
- Regulation of the Escherichia coli cad operon: location of a site required for acid inductionJournal of Bacteriology, 1992
- Nucleotide sequence of the Escherichia coli cad operon: a system for neutralization of low extracellular pHJournal of Bacteriology, 1992