Clinical evaluation of clobetasone butyrate eye drops in the treatment of anterior uveitis and its effects on intraocular pressure.

Publisher Website
Google Scholar
Abstract
Clobetasone butyrate was formulated as a new steroid preparation for use in ophthalmology and was compared with prednisolone phosphate and betamethasone phosphate in the treatment of [human] anterior uveitis. The results from 4 double-blind, between-patient studies showed that all 3 treatments are effective in reducing the signs and symptoms of this intraocular disease. Of those patients receiving clobetasone butyrate, 87% had a good or satisfactory response. No differences in therapeutic efficacy were observed between these 3 steroid treatments. Clobetasone butyrate had little effect on intraocular pressure when compared with dexamethasone or hydrocortisone, both of which cause a significant rise in intraocular pressure.