Abstract
The extent of original learning during unilateral spreading depression, and the amount of interdepression training with both hemispheres nondepressed were related to interhemispheric transfer of avoidance behavior in rats. 3 levels of original learning (0, 3, and 15 avoidance responses) were combined with 4 levels of interdepression training (0, 1, 5, and 10 avoidance responses) in a factorial design (N=72). Results were (a) Extended original learning followed by 5 interdepression responses produced significant positive interhemispheric transfer. (b) Minimal original learning followed by either 1 or 5 interdepression responses produced instances of negative interhemispheric transfer. (c) Extensive interdepression training (10 avoidance responses) produced asymptotic transfer performance regardless of the extent of original learning conditions.

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