Hibernomas are characterized by rearrangements of chromosome bands 11q13‐21

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Abstract
Cytogenetic analysis revealed structural rearrangements of 11q13‐21 in 9 lipogenic tumors—4 hibernomas, 4 typical lipomas and I mixed myxoid and well‐differentiated liposarcoma. Two hibernomas and all lipomas simultaneously showed aberrations attributable to previously recognized cytogenetic subgroups among benign adipose tissue tumors, i.e., supernumerary ring chromosomes or rearrangements of 6p, 12q13‐15, or 13q. The sole anomaly in the liposarcoma was a 4‐way translocation t(9;11;22;12)(q21;q13;q11;q13), an aberration that has not previously been detected in either myxoid or well‐differentiated liposarcomas. Together with our 4 cases, a total of 7 cytogenetically aberrant hibernomas have been reported. Five tumors have shown rearrangements of 11q13 and 2 of 11q21, indicating that this segment of chromosome 11 harbors one or more genes of importance in hibernoma development. Rearrangements of 11q13‐21 also appear to be frequent in typical lipomas; a total of 8 typical lipomas with 11q13‐21 changes have been described, including those in our series. In all but I, however, breakpoints were also found in 6p, 12q13‐15, or 13q.