Serologic Findings with Hepatitis B in Hemophilia

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Abstract
To the Editor: In their article, "Asymptomatic Structural Liver Disease in Hemophilia," which appeared in the June 22 issue of the Journal, Spero and his colleagues, using indirect immunofluorescence, presented data implicating the hepatitis B virus in the chronic liver disease of hemophilic patients, suggested that the mechanism might be through formation of viral-anti-viral immune complexes and questioned the accepted role of antibodies to the hepatitis B surface antigen (anti-HBs) in protection against hepatitis B.In a recently completed study of serum specimens from 159 hemophilic patients at the Bureau of Biologics, those with serologic evidence of infection with . . .

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