Risk Factors in Ischemic Heart Disease

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Abstract
Data obtained from the Cardiovascular Health Center, a long-term prospective study of the development of coronary heart disease in a group of male civil servants age 39-55 at the start of the study in 1953, were used to describe the profiles of the coronary-prone and of the noncoronary subject. The noncoronary individual is slightly younger, less hypercholesterolemic, less hypertensive, less obese and smokes less than the coronary-prone individual. The 6-year incidence of coronary heart disease has been approximately 3 times greater in hypercholesterolemic subjects, 2.5 times greater in hypertensives, and twice as high in heavy smokers compared with normal subjects. Hypertension accompanied by left ventricular enlargement is associated with a still greater differential risk. In heavy smokers the risk increases with the duration of the habit. Although these differential risk factors are highly significant, the wide overlap of normal and abnormal values does not permit precise identification of the vulnerable individual.

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