Electrocardiographic Changes Produced on the Syrian Hamster (Cricetus auratus) by Diphtherial Toxins
- 1 October 1949
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 72 (1) , 58-59
- https://doi.org/10.3181/00379727-72-17331
Abstract
Limb lead ecg''s. of the golden hamster (Cricetus auratus) were taken on an amplifier instrument. The normal pattern was established. M.L.D. of acid treated toxins (p H 6.7) of Coryne-bacteriumdiphtheriae(Park No.8 strain) did not cause apparent neurotoxic and ecg. abnormalities. Alkaline-treated (pH 8.5) toxins caused paresis and marked ecg. changes which frequently preceded the paresis; animals receiving sublethal doses showed still ecg. changes after the neurological symptoms had disappeared. Ecg. examination seems to be a very sensitive method of measuring the action of certain diphtherial toxins.Keywords
This publication has 1 reference indexed in Scilit:
- Neurotoxic Symptoms Produced in the Syrian Hamster (Cricetus Auratus) by Diphtherial ToxinThe Journal of Immunology, 1948