Close linkage of MEN2A with RBP3 locus in Japanese kindreds
- 1 June 1989
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 82 (3) , 287-288
- https://doi.org/10.1007/bf00291173
Abstract
The gene responsible for multiple endocrine neoplasia type 2A (MEN2A) has recently been assigned to the pericentromeric region of chromsome 10 in European Caucasian kindreds by linkage analysis using a DNA marker, interstitial retinol-binding protein 3 (RBP3). We have found tight linkage between the MEN2A and RBP3 loci in Japanese MEN2A kindreds. The maximum lod score is 5.19 at a recombination fraction of 0.00. This result suggests that mutation of a certain gene close to RBP3 is responsible for MEN2A irrespective of ethnic backgrounds.Keywords
This publication has 6 references indexed in Scilit:
- SCREENING MULTIPLE ENDOCRINE NEOPLASIA TYPE 2A FAMILIES USING DNA MARKERSThe Lancet, 1988
- Assignment of multiple endocrine neoplasia type 2A to chromosome 10 by linkageNature, 1987
- A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10Nature, 1987
- Bgl II RFLP recognized by a human IRBP cDNA localized to chromosome 10Nucleic Acids Research, 1987
- Multiple endocrine neoplasia type 2 syndromes in Japan.1984
- Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.1974