Comparison of the Chromosome Damage and Its Dose Response after Medical Whole-body Exposure to60Co γ-rays and Irradiation of Bloodin Vitro
- 1 January 1974
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
- Vol. 26 (1) , 31-37
- https://doi.org/10.1080/09553007414550911
Abstract
Fifteen patients with advanced cancer have been exposed to a medical whole-body 60Co γ-irradiation with doses of 10, 19 and 29 rads before local palliative radiation therapy. Chromosome analyses were carried out in lymphocytes of blood samples obtained before, immediately after, and 24 hours after the exposure of the patients as well as after in vitro irradiation of the patients' blood. A comparison of the frequencies of dicentrics + ring chromosomes revealed no significant differences neither between the two sampling times after exposure of the patients, nor between either in vivo or in vitro samples. The dose-response relations were linear. Due to the low aberration yields occurring in low dose-ranges, the applicability of chromosome damage to a biological dosimetry is a statistical problem. A meaningful dose estimation for a single person based on the 200 cells usually analysed is impossible.Keywords
This publication has 6 references indexed in Scilit:
- AnnouncementsThe International Journal of Applied Radiation and Isotopes, 1973
- Radiation-Induced Human Chromosome Aberration Yields Following an Accidental Whole-Body Exposure to 60 Co g-RaysRadiation Research, 1972
- Radiation-induced human chromosome aberrations: II. Human in vitro irradiation compared to in vitro and in vivo irradiation of marmoset leukocytesMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1971
- Chromosome Damage Induced by RadiationNature, 1968
- TYPES AND RATES OF X-RAY-INDUCED CHROMOSOME ABERRATIONS IN HUMAN BLOOD IRRADIATED IN VITROProceedings of the National Academy of Sciences, 1962