Substances derived from 4-de-N-methylfortimicin B.
- 1 January 1981
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 34 (6) , 691-700
- https://doi.org/10.7164/antibiotics.34.691
Abstract
The preparation of 4-de-N-methylfortimicin A analogs and the preparation of 4-de-N-methyl-4-N-(.beta.-aminoethyl)-4-N-ethylfortimicin B is reported. The 4-N-methyl group in fortimicin analogs is essential for antibacterial activity since neither the 4-de-N-methylfortimicin A nor the 4-de-N-methyl-4-N-(.beta.-aminoethyl)-4-N-ethylfortimicin B exhibited useful biological activity.This publication has 2 references indexed in Scilit:
- Chemical modification of fortimicins: Preparation of 4-N-substituted fortimicin B.The Journal of Antibiotics, 1979
- Fortimicins A and B, new aminoglycoside antibiotics. I. Producing organism, fermentation a biological properties of fortimicins.The Journal of Antibiotics, 1977