A note on synthesis and reactivity towards DNA of glycidonitrile, the epoxide of acrylonitrile

1 January 1983

journal article
research article
Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research

Vol. 4 (2) , 235-237
https://doi.org/10.1093/carcin/4.2.235

Abstract

Different ways have been used to synthesize glycidonitrile, the epoxide of acrylonitrile. The reaction product has been characterized by n.m.r. spectroscopy. While glycidonitrile-induced strand breaks in SV40 phage DNA in vitro , acrylonitrile did not.

Keywords

EPOXIDE
SV40
PHAGE
STRAND
BREAKS
SYNTHESIS AND REACTIVITY
N.M.R
NOTE ON SYNTHESIS
REACTIVITY TOWARDS DNA