Syntheses and Immunoadjuvant Activity of Some Carbohydrate Analogs ofN-Acetylmuramyl-l-alanyl-d-isoglutamme

1 June 1980

journal article
research article
Published by Oxford University Press (OUP) in Agricultural and Biological Chemistry

Vol. 44 (6) , 1301-1308
https://doi.org/10.1080/00021369.1980.10864112

Abstract

Carbohydrate analogs of N-acetylmuramyl-l-alanyl-d-isoglutamine, such as 2-acetamido-2, 6-dideoxy-3-O-(d-2-propionyl-l-alanyl-d-isoglutamine-d-glucopyranose (11), 2-acetamido-6-amino-2, 6-dideoxy-3-O-(d-2-propionyl-l-alanyl-d-isoglutamine)-d-glucopyranose (12), and 2-acetamido-2-deoxy-3-O-(d-2-propionyl-l-alanyl-d-isoglutamine)-d-xylopyranose (18) were synthesized, and their immunoadjuvant activities were examined to clarify their structural requirements for activity in the carbohydrate moiety.

This publication has 2 references indexed in Scilit:

Adjuvant activity of mycobacterial fractions: adjuvant activity of synthetic N-acetylmuramyl-dipeptide and the related compounds
Infection and Immunity, 1976
SYNTHESIS OF PEPTIDE FRAGMENT OF PEPTIDOGLYCANE FROM CELL WALL OF 3 GRAM-POSITIVE BACTERIA AND OF PEPTIDES OF ANALOGOUS STRUCTURE
1967